Short-term prognostic value of the neutrophil/ lymphocyte ratio in patients with acute kidney injury

Authors

  • Sergio Orlando Escalona-González Policlínico Universitario “Manuel Fajardo Rivero”. Las Tunas. https://orcid.org/0000-0003-4261-6842
  • Zoraida Caridad González-Milán Hospital General Docente “Dr. Ernesto Guevara de la Serna”. Las Tunas. Universidad de Ciencias Médicas de Las Tunas. Facultad de Ciencias Médicas “Dr. Zoilo Enrique Marinello Vidaurreta”. Las Tunas. https://orcid.org/0009-0006-5577-7089
  • Aliosky Montero-Cala Hospital General Docente “Dr. Ernesto Guevara de la Serna”. Las Tunas. Universidad de Ciencias Médicas de Las Tunas. Facultad de Ciencias Médicas “Dr. Zoilo Enrique Marinello Vidaurreta”. Las Tunas. https://orcid.org/0000-0002-3981-4971
  • Fidel Peña-Espinosa Hospital General Docente "Dr. Ernesto Guevara de la Serna". Las Tunas. https://orcid.org/0009-0001-7488-7068
  • Estrella Romero-Valdivia Hospital General Docente “Dr. Ernesto Guevara de la Serna”. Las Tunas. Universidad de Ciencias Médicas de Las Tunas. Facultad de Ciencias Médicas “Dr. Zoilo Enrique Marinello Vidaurreta”. Las Tunas. https://orcid.org/0000-0003-0623-5815
  • Beatriz Ricardo-Paez Universidad de Ciencias Médicas de Las Tunas. Facultad de Ciencias Médicas “Dr. Zoilo Enrique Marinello Vidaurreta”. Las Tunas. https://orcid.org/0009-0002-5046-8085

Keywords:

NEUTROPHILS, DIALYSIS RENAL, ACUTE KIDNEY INJURY, MORTALITY, PROGNOSIS, LYMPHOCYTES

Abstract

Background: mortality in patients with acute kidney injury is high and sometimes low- and medium-income health systems lack tools capable of predicting the prognosis of these patients.

Objective: to estimate the prognostic value of short-term mortality of the neutrophil/lymphocyte ratio in patients with acute kidney injury in an intensive unit care.

Methods:  a retrospective cohort analytical study was conducted in 124 patients with acute kidney injury from January 1, 2022 to December 31, 2022. A k-means cluster analysis was performed, requesting the creation of three clusters according to values of the neutrophil/lymphocyte ratio. Survival curves were constructed using the Kaplan-Meier method and the survival means were compared using the Log-Rank test. The optimal cut-off point of the neutrophil/lymphocyte ratio was established for the prediction of mortality and the discriminatory capacity was evaluated through the area under the curve of the C statistic.

Results: mortality was higher in the third tercil (76.74 %). The deceased patients had a significantly higher median index than the survivors (6.73 vs. 4.55; p<0.001). The discriminatory power was good, C index: 0.847 (95 % CI: 0.780-0.913; p<0.001) and the cut-off point was 4.88 (95 % CI: 4.43-6.35), above which was associated with a significantly lower survival (81 vs. 149 hours; p<0.001).

Conclusions: the present study shows the neutrophil/lymphocyte ratio with abilities to predict mortality in patients with acute kidney injury.

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Author Biographies

Sergio Orlando Escalona-González, Policlínico Universitario “Manuel Fajardo Rivero”. Las Tunas.

Especialista de Primer Grado en Medicina General Integral. Investigador Agregado

Zoraida Caridad González-Milán, Hospital General Docente “Dr. Ernesto Guevara de la Serna”. Las Tunas. Universidad de Ciencias Médicas de Las Tunas. Facultad de Ciencias Médicas “Dr. Zoilo Enrique Marinello Vidaurreta”. Las Tunas.

Especialista de Primer Grado en Nefrología y Medicina General Integral. Máster en Longevidad Satisfactoria. Profesor Auxiliar

Aliosky Montero-Cala, Hospital General Docente “Dr. Ernesto Guevara de la Serna”. Las Tunas. Universidad de Ciencias Médicas de Las Tunas. Facultad de Ciencias Médicas “Dr. Zoilo Enrique Marinello Vidaurreta”. Las Tunas.

Especialista de Primer Grado en Medicina Intensiva y Emergencias. Máster en Urgencias Médicas. Profesor Auxiliar

Fidel Peña-Espinosa, Hospital General Docente "Dr. Ernesto Guevara de la Serna". Las Tunas.

Licenciado en Enfermería

Estrella Romero-Valdivia, Hospital General Docente “Dr. Ernesto Guevara de la Serna”. Las Tunas. Universidad de Ciencias Médicas de Las Tunas. Facultad de Ciencias Médicas “Dr. Zoilo Enrique Marinello Vidaurreta”. Las Tunas.

Especialista de Primer grado en Medicina Intensiva y Emergencias. Profesor Asistente

Beatriz Ricardo-Paez, Universidad de Ciencias Médicas de Las Tunas. Facultad de Ciencias Médicas “Dr. Zoilo Enrique Marinello Vidaurreta”. Las Tunas.

Estudiante de quinto año de Medicina. Alumna ayudante en Nefrología

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Published

2023-10-26

How to Cite

1.
Escalona-González SO, González-Milán ZC, Montero-Cala A, Peña-Espinosa F, Romero-Valdivia E, Ricardo-Paez B. Short-term prognostic value of the neutrophil/ lymphocyte ratio in patients with acute kidney injury. Rev. electron. Zoilo [Internet]. 2023 Oct. 26 [cited 2025 Sep. 16];48:e3515. Available from: https://revzoilomarinello.sld.cu/index.php/zmv/article/view/3515

Issue

Vol. 48 (2023): Continuous Article Publication

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Original articles

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