Effectiveness of magnesium sulfate as an adjuvant to anesthesia for the patient with hip fracture

Authors

  • Zaily Fuentes-Díaz Hospital General Docente “Manuel Ascunce Domenech”. Camagüey. Universidad de Ciencias Médicas de Camagüey. Camagüey.
  • Orlando Rodríguez-Salazar Hospital General Docente “Manuel Ascunce Domenech”. Camagüey. Universidad de Ciencias Médicas de Camagüey. Camagüey.
  • Elizabeth Vidor-Guerra Universidad de Ciencias Médicas de Camagüey. Camagüey.
  • Luis Manuel Amador-Aguilar Universidad de Ciencias Médicas de Camagüey. Camagüey.

Keywords:

HIP FRACTURES, SURGICAL PROCEDURES, OPERATIVE, ADJUVANTS, ANESTHESIA, MAGNESIUM SULFATE

Abstract

Background: the anesthetic effect of magnesium sulfate is related to several mechanisms as an antagonist of the N-methyl-D-aspartate receptors.

Objective: to evaluate the adjuvant effectiveness of magnesium sulfate in patients aged 60 years and older who underwent surgery for hip fracture at the "Manuel Ascunce Domenech" General Teaching Hospital of the province of Camagüey, from November 2014 to September 2018.

Methods: an analytical, prospective case-control study was conducted with the patients and at the institution and period of time declared in the objective. The sample included 180 patients distributed in a simple 1:1 random in the control and study groups. Those included in the latter were administered magnesium sulfate during the preoperative care.

Results: we verified a higher risk of hip fracture in female patients, and in those aged 65 years and older; the largest number of patients underwent an intrathecal neuroaxial technique, without changes in the assessed clinical parameters. The duration of analgesia at 12 hours postoperatively was seven times higher in those of the study group with respect to the control group.

Conclusions: the perioperative parenteral administration of magnesium sulfate in patients with the diagnosis of hip fracture was effective, extending the duration of analgesia.

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Author Biographies

Zaily Fuentes-Díaz, Hospital General Docente “Manuel Ascunce Domenech”. Camagüey. Universidad de Ciencias Médicas de Camagüey. Camagüey.

Especialista de Segundo Grado en Anestesiología y Reanimación. Doctora en Ciencias Médicas. Investigador Agregado. Profesora Auxiliar

Orlando Rodríguez-Salazar, Hospital General Docente “Manuel Ascunce Domenech”. Camagüey. Universidad de Ciencias Médicas de Camagüey. Camagüey.

Especialista de Segundo Grado en Cirugía Plástica y Quemados. Máster en Urgencias Médicas. Investigador Agregado. Profesor Asistente

Elizabeth Vidor-Guerra, Universidad de Ciencias Médicas de Camagüey. Camagüey.

Especialista de Segundo Grado en Fisiología y de Primer Grado en Medicina General Integral. Profesora Auxiliar

Luis Manuel Amador-Aguilar, Universidad de Ciencias Médicas de Camagüey. Camagüey.

Especialista de Primer Grado en Medicina General Integral y en Bioestadística. Profesor Instructor

References

Rodríguez Rubio L. Empleo del sulfato de magnesio como adyuvante durante la anestesia general, en pacientes ASA I y II: revisión sistemática y meta-análisis [tesis doctoral]. Albacete: Universidad de Castilla- La Mancha. Facultad de Medicina de Albacete; 2015 [citado 5 de junio 2018]. Disponible en: https://ruidera.uclm.es/xmlui/bitstream/handle/10578/10557/TESIS%20Rodr%C3%ADguez%20Rubio.pdf?sequence=1.

Mahajan L, Kaur M, Gupta R, Aujla KS, Singh A, Kaur A. Attenuation of the pressor responses to laryngoscopy and endotracheal intubation with intravenous dexmedetomidine versus magnesium sulphate under bispectral index-controlled anaesthesia: A placebo-controlled prospective randomised trial. Indian J Anaesth [revista en internet]. 2018 [citado 5 de junio 2018]; 62(5). Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971621/.

Bayram A, Ülgey A, Günes I, Ketenci I, Capar A, Esmaoglu A, et al. Comparación entre el sulfato de magnesio y ladexmedetomidina en hipotensión controlada durante. Cirugía funcional endoscópica de los senos paranasales. Rev Bras Anestesiol [revista en internet]. 2015 [citado 5 de junio 2018]; 65(1). Disponible en: https://www.sciencedirect.com/science/article/pii/S2255496314000932.

Castillo Álvarez Ed C. Sulfato de magnesio como adyuvante para el manejo del dolor postoperatorio en pacientes sometidos a cirugía general [tesis]. México, Veracruz: Universidad Veracruzana. Instituto mexicano del seguro social; 2014 [citado 5 de junio 2018]. Disponible en: https://www.uv.mx/blogs/favem2014/files/2014/07/Tesis-Edna.pdf.

Vargas-Hernández JJ. Anestesia libre de opioides. Anestesiología en oncología [revista en internet]. 2014 [citado 5 de junio 2018]; 37(Supl1). Disponible en: http://www.medigraphic.com/pdfs/rma/cma-2014/cmas141i.pdf.

Dávila Cabo de Villa E. Evaluación preoperatoria del paciente quirúrgico. En: Dávila Cabo de Villa E, Gómez Brito C, Álvarez Bárzaga M, Sainz Cabrera H, Navarrete Zuazo VM, Rodríguez Varela M, et al. Anestesiología Clínica. La Habana: Editorial Ciencias Médicas; 2013. p. 61-74.

Horlocker TT, Kopp LS, Wedwl DJ. Bloqueos nerviosos periféricos. En: Miller RD, Eriksson LI, Fleischer LA, Wiener-Kronish JP, Young WL, Kelz MB, et al. Miller Anestesia. T2. 8va ed. New York: McGraw-Hill; 2015. p. 1740-41.

Hsu CC, Lin CC, Wang YC, Chen HJ, Chiu YC, Chang CC, et al. Increased Risk for Hip Fractures among Patients with Cholangitis: A Nationwide Population-Based Study. Biomed Res Int. [revista en internet]. 2018 [citado 5 de junio 2018]; 2018(5): 8928174. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008616/.

Van Nieuwpoort IC, Twisk JWR, Curfs LMG, Lips P, Drent ML. Body composition, adipokines, bone mineral density and bone remodeling markers in relation to IGF-1 levels in adults with Prader-Willi syndrome. International Journal of Pediatric Endocrinology [revista en internet]. 2018 [citado 5 de junio 2018]; 2018(1). Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771040/.

Al-Daghri NM, Torretta E, Capitanio D, Fania C, Guerini FR, Sabico SB, et al. Intermediate and low abundant protein analysis of vitamin D deficient obese and non-obese subjects by MALDI-profiling. Scientific Reports [revista en internet]. 2017 [citado 5 de junio 2018]; 7(1): 12633. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626753/.

Zeng Y, Zhang L, Zhu W, He H, Sheng H, Tian Q, et al. Network based subcellular proteomics in monocyte membrane revealed novel candidate genes involved in osteoporosis. Osteoporosis international: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA [revista en internet]. 2017 [citado 5 de junio 2018]; 28(10): 3033-3042. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812280/.

Uzer G, Fuchs RK, Rubin J, Thompson WR. Plasma and Nuclear Membranes Convey Mechanical Information to Regulate Mesenchymal Stem Cell Lineage. Stem cells (Dayton, Ohio) [revista en internet]. 2016 [citado 5 de junio 2018]; 34(6): 1455-1463. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546909/.

Baccaro LF, Conde DM, Costa-Paiva L, Pinto-Neto AM. The epidemiology and management of postmenopausal osteoporosis: a viewpoint from Brazil. Clinical Interventions in Aging [revista en internet]. 2015 [citado 5 de junio 2018]; 10: 583-591. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374649/.

Amaro-Gahete FJ, Jurado-Fasoli L, Espuch-Oliver A, Robles-Gonzalez L, Navarro-Lomas G, de Haro T, et al. Exercise training as S-Klotho protein stimulator in sedentary healthy adults: Rationale, design, and methodology. Contemporary Clinical Trials Communications [revista en internet]. 2018 [citado 5 de junio 2018]; 11: 10-19. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022251/.

Taylor S, Hu R, Pacheco E, Locher K, Pyrah I, Ominsky MS, et al. Differential time-dependent transcriptional changes in the osteoblast lineage in cortical bone associated with sclerostin antibody treatment in ovariectomized rats. Bone Reports [revista en internet]. 2018 [citado 5 de junio 2018]; 8: 95-103. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020117/.

Duerksen D, Pinto-Sanchez MI, Anca A. Management of bone health in patients with celiac disease: Practical guide for clinicians. Canadian Family Physician [revista en internet]. 2018 [citado 5 de junio 2018]; 64(6): 433-438. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999247/.

Geissler S, Textor M, Stumpp S. Loss of murine Gfi1 causes neutropenia and induces osteoporosis depending on the pathogen load and systemic inflammation. PLoS ONE [revista en internet]. 2018 [citado 5 de junio 2018]; 13(6): e0198510. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991660/.

Sistema de Información Estadística Nacional de Demografía. Oficina Nacional de Estadística e Información. Ministerio de Salud Pública de Cuba. Informe de balance 2017. [en línea]. La Habana: MINSAP; 2018, Feb. [citado 2018 mayo 23]. Disponible en: http://www.sld.cu/servicios/estadísticas/

Ministerio de Salud Pública. Dirección Nacional de Registros Médicos y Estadísticas de Salud. 10 primeras causas de muerte por grupos de edad y sexo en el adulto mayor [en línea]. La Habana: MINSAP; 2018 [citado 2018 mayo 23]. Disponible en: http://www.sld.cu/servicios/estadísticas/.

Nagre AS, Jambure N. Single bolus dose of epidural magnesium prolongs the duration of analgesia in cardiac patients undergoing vascular surgeries. Indian J Anaesth [revista en internet]. 2017, Oct [citado 5 de junio 2018]; 61(10). Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664889/.

Abd-Elsalam KA, Fares KM, Mohamed MA, Mohamed MF, El-Rahman AMA, Tohamy MM. Efficacy of Magnesium Sulfate Added to Local Anesthetic in a Transversus Abdominis Plane Block for Analgesia Following Total Abdominal Hysterectomy: A Randomized Trial. Pain Physician [revista en internet]. 2017, Nov [citado 5 de junio 2018]; 20(7). Disponible en: http://www.painphysicianjournal.com/current/pdf?article=NDcwNQ%3D%3D&journal=108.

Mokaram DM, Foruzin F. The Analgesic Efficacy of Intrathecal Bupivacaine and Fentanyl with Added Neostigmine or Magnesium Sulphate. Anesth Pain Med [revista en internet]. 2016, Sep [citado 5 de junio 2018]; 6(6). Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560647/.

Khandelwal M, Dutta D, Bafna U, Chauhan S, Jetley P, Mitra S. Comparison of intrathecal clonidine and magnesium sulphate used as an adjuvant with hyperbaric bupivacaine in lower abdominal surgery. Indian J Anaesth [revista en internet]. 2017, Aug [citado 5 de junio 2018]; 61(8). Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579858/.

Katiyar S, Dwivedi C, Tipu S, Jain RK. Comparison of different doses of magnesium sulphate and fentanyl as adjuvants to bupivacaine for infraumbilical surgeries under subarachnoid block. Indian J Anaesth [revista en internet]. 2015, Aug [citado 5 de junio 2018]; 59(8). Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551023/.

Soliman R, Fouad E. The effects of dexmedetomidine and magnesium sulphate in adult patients undergoing endoscopic transnasal transsphenoidal resection of pituitary adenoma: A double-blind randomised study. Indian J Anaesth [revista en internet]. 2017, May [citado 5 de junio 2018]; 61(5). Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444220/.

Sun J, Feng X, Zhu Q, Lin W, Guo H, Ansong E, et al. Analgesic effect of perineural magnesium sulphate for sciatic nerve block for diabetic toe amputation: A randomized trial. PLoS One [revista en internet]. 2017, May [citado 5 de junio 2018]; 12(5). Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413065/#__ffn_sectitle.

Verma V, Rana S, Chaudhary SK, Singh J, Verma RK, Sood S. A dose-finding randomised controlled trial of magnesium sulphate as an adjuvant in ultrasound-guided supraclavicular brachial plexus block. Indian J Anaesth [revista en internet]. 2017, Mar [citado 5 de junio 2018]; 61(3). Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372407/.

Srivastava VK, Mishra A, Agrawal S, Kumar S, Sharma S, Kumar R, et al. Comparative evaluation of dexmedetomidine and magnesium sulphate on propofol consumption, haemodynamics and postoperative recovery in Spine surgery: A Prospective, randomized, placebo controlled, double-blind study. Adv Pharm Bull [revista en internet]. 2016, Mar [citado 5 de junio 2018]; 6(1). Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845545/.

Attari MA, Najafabadi FM, Talakoob R, Abrishamkar S, Taravati H. Comparison of the effects of 3 methods of intrathecal bupivacaine, bupivacaine-fentanyl, and bupivacaine-fentanyl-magnesium sulfate on sensory motor blocks and postoperative pain in patients undergoing lumbar disk herniation surgery. J Neurosurg Anesthesiol [revista en internet]. 2016, Enero [citado 5 de junio 2018]; 28(1). Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223037/.

Zárate Gracia A, Madrigal Hernández M, Echegollen Guzmán A, Bravo Soto G. Efectos analgésicos del sulfato de magnesio como adyuvante a la bupivacaina hiperbárica subaracnoidea para colecistectomía laparoscópica: Ensayo clínico, doble ciego aleatorizado. Revista Mexicana de Ciencias Farmacéuticas [revista en internet]. 2015, Oct-Dic [citado 5 de junio 2018]; 46(4). Disponible en: http://www.redalyc.org/pdf/579/57949344006.pdf.

Published

2018-11-13

How to Cite

1.
Fuentes-Díaz Z, Rodríguez-Salazar O, Vidor-Guerra E, Amador-Aguilar LM. Effectiveness of magnesium sulfate as an adjuvant to anesthesia for the patient with hip fracture. Rev. electron. Zoilo [Internet]. 2018 Nov. 13 [cited 2025 Nov. 8];44(1). Available from: https://revzoilomarinello.sld.cu/index.php/zmv/article/view/1561

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