Molecular mimicry and interactions between SARS-CoV-2 S glycoprotein and human proteins
Keywords:
ADAPTATION, BIOLOGICAL, SARS VIRUS, CORONAVIRUS INFECTIONS, SARS-COV-2, COVID-19Abstract
Background: mimicry between SARS-CoV-2 S glycoprotein and human molecules may be part of the mechanisms involved in the damages caused by the virus to target organs.
Objective: to identify, with the use of bioinformatic tools, the molecular mimicry and interactions between S glycoprotein and human proteins.
Methods: five SARS-CoV-2 S glycoprotein T cell epitopes, presented by HLA-A*0201 and HLA-DRB1*0301, were selected to search for equivalent sequences in TANTIGEN, a tumor antigens database, using BLASTP tool. We chose those human proteins that shared at least six amino acids and more than 60 % of equivalence. Their characteristics were taken from UniProt database, and the representation of their interactions with other human proteins was modeled in STRING. The results were compared to predicted interactions of S glycoprotein and human proteins, according to Bio-Grid.
Results: in TANTIGEN database 11 human proteins were found with equivalence to gp S T epitopes. Among them, CSPG4 is reported in S glycoprotein interactions. The identified proteins take part in metabolic, signaling and cellular activation. Ten molecules interacting with at least one of the human proteins were identified: F2, USP10, SMU1, LPHN2 and GPC3, which appeared as potential interactors with SARS-CoV-2 S glycoprotein.
Conclusions: mimicry between S glycoprotein epitopes and human proteins may be part of the pathogenic mechanisms during the infection due to SARS-CoV-2.
Downloads
References
Li J, Liu HH, Yin XD, Li CC, Wang J. COVID-19 illness and autoimmune diseases: recent insights. Inflammation Research [revista en internet]. 2021 [citado 24 de mayo 2021]; 70(4): 407-428. Disponible en: https://doi.org/10.1007/s00011-021-01446-1.
Serrano-Barrera OR. Predicción de la inmunogenicidad de la proteína del SARS-CoV-2 responsable de la infección COVID-19 en humanos. Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta [revista en internet]. 2020 [citado 24 de mayo 2021]; 45(3). Disponible en: http://revzoilomarinello.sld.cu/index.php/zmv/article/view/2270.
Bohn MK, Hall A, Sepiashvili L, Jung B, Steele S, Adeli K. Pathophysiology of COVID-19: Mechanisms Underlying Disease Severity and Progression. Physiology [revista en internet]. 2020 [citado 24 de mayo 2021]; 35(5): 288-301. Disponible en: https://doi.org/10.1152/physiol.00019.2020.
Liu Y, Sawalhab AH, Lu Q. COVID-19 and autoimmune diseases. Curr Opin Rheumatol [revista en internet]. 2021 [citado 24 de mayo 2021]; 33(2): 155-162. Disponible en: https://dx.doi.org/10.1097%2FBOR.0000000000000776.
Abbas AK, Lichtman AH, Pillai Shiv. Inmunología Celular y Molecular. 8va ed. Barcelona: Elsevier Saunders; 2015.
Song J, Han J, Liu F, Chen X, Qian S, Wang Y, et al. Systematic Analysis of Coronavirus Disease 2019 (COVID-19) Receptor ACE2 in Malignant Tumors: Pan-Cancer Analysis. Front. Mol. Biosci. [revista internet]. 2020 [citado 24 May 2021]; 7: 569414. Disponible en: https://dx.doi.org/10.3389%2Ffmolb.2020.569414.
Bao R, Hernandez K, Huang L, Luke JJ. ACE2 and TMPRSS2 expression by clinical, HLA, immune, and microbial correlates across 34 human cancers and matched normal tissues: implications for SARS-CoV-2 COVID-19. Journal for Immuno Therapy of Cancer [revista en internet]. 2020 [citado 24 de mayo 2021]; 8(2): e001020. Disponible en: https://dx.doi.org/10.1136%2Fjitc-2020-001020.
Gottschalk G, Knox K, Roy A. ACE2: At the crossroad of COVID-19 and lung cancer. Gene Reports [revista en internet]. 2021 [citado 24 de mayo 2021]; 23(2021): 101077. Disponible en: https://doi.org/10.1016/j.genrep.2021.101077.
Karaderi T, Bareke H, Kunter I, Seytanoglu A, Cagnan I, Balci D, et al. Host Genetics at the Intersection of Autoimmunity and COVID-19: A Potential Key for Heterogeneous COVID-19 Severity. Front. Immunol. [revista en internet]. 2020 [citado 24 de mayo 2021]; 11: 586111. Disponible en: https://dx.doi.org/10.3389%2Ffimmu.2020.586111.
Shah S, Danda D, Kavadichanda C, Das S, Adarsh MB, Negi V. Autoimmune and rheumatic musculoskeletal diseases as a consequence of SARS-CoV-2 infection and its treatment. Rheumatology International [revista en internet]. 2020 [citado 24 de mayo 2021]; 40: 1539-1554. Disponible en: https://link.springer.com/article/10.1007/s00296-020-04639-9.
Paradoa ML, Middleton D, Acosta A, Sarmiento ME, Leyva J. Genes HLA en una muestra de la población cubana. Vaccimonitor [revista en internet]. 2000, Sep [citado 24 de mayo 2021]; 9(3): 1-5. Disponible en: https://www.redalyc.org/pdf/2034/203415536001.pdf.
Ferrer A, Nazábal M, Companioni O, de Cossío MEF, Camacho H, Cintado A, et al. HLA class I polymorphism in the Cuban population. Human Immunology. [revista en internet]. 2007 [citado 24 de mayo 2021]; 68(11): 918-927. Disponible en: https://doi.org/10.1016/j.humimm.2007.09.002.
Zhang G, Chitkushev L, Olsen LR, Keskin DB, Brusic V. TANTIGEN 2.0: a knowledge base of tumor T cell antigens and epitopes. BMC Bioinformatics [revista en internet]. 2021 [citado 24 de mayo 2021]; 22: 40. Disponible en: https://doi.org/10.1186/s12859-021-03962-7.rtu.
Oldstone MBA. Molecular Mimicry as a Mechanism for the Cause and as a Probe Uncovering Etiologic Agent(s) of Autoimmune Disease. Molecular Mimicry [revista en internet]. 1989 [citado 24 de mayo 2021]; (145). Disponible en: https://doi.org/10.1007/978-3-642-74594-2_11.
Dotan A, Muller S, Kanduc D, David P, Halpert G, Shoenfeld Y. The SARS-CoV-2 as an instrumental trigger of autoimmunity. Autoimmunity Reviews [revista en internet]. 2021 [citado 24 de mayo 2021]; 20(4): 102792. Disponible en: https://doi.org/10.1016/j.autrev.2021.102792.
Batista-Duharte A, Téllez B, Tamayo M, Portuondo D, Cabrera O, Sierra G, et al. Identificación in silico del mimetismo molecular entre epitopes T de Neisseria meningitidis B y el proteoma humano. Rev. Peru Med. Exp. Salud Pública [revista en internet]. 2013 [citado 24 de mayo 2021]; 30(3): 441-5. Disponible en: https://doi.org/10.17843/rpmesp.2013.303.281.
Adiguzel Y. Molecular mimicry between SARS-CoV-2 and human proteins. Autoimmunity Reviews [revista en internet]. 2021 [citado 24 de mayo 2021]; 20(4): 102791. Disponibe en: https://dx.doi.org/10.1016%2Fj.autrev.2021.102791.
He C, Hua X, Shun S, Li S, Wang J, Huang X. Integrated Bioinformatic Analysis of SARS-CoV-2 Infection Related Genes ACE2, BSG and TMPRSS2 in Aerodigestive Cancers. Journal of Inflammation Research [revista en internet]. 2021 [citado 24 de mayo 2021]; 14: 791-802. Disponible en: https://dx.doi.org/10.2147%2FJIR.S300127.
Dettore GM, Patel M, Gennari A, Pentheroudakis G, Romano E, Cortellini A, et al. The systemic pro-inflammatory response: targeting the dangerous liaison between COVID-19 and cancer. ESMO OPEN CANCER HORIZONS [revista en internet]. 2021 [citado 24 de mayo 2021]; 6(3). Disponible en: https://doi.org/10.1016/j.esmoop.2021.100123.
Bora VR, Patel BM. The Deadly Duo of COVID-19 and Cancer! Front. Mol. Biosci. [revista en internet]. 2021 [citado 24 de mayo 2021]; 8: 643004. Disponible en: https://doi.org/10.3389/fmolb.2021.643004.
Catalá Gonzalo A, Galván Casas C. COVID-19 y piel. Actas Dermosifiliogr. [revista en internet]. 2020 [citado 24 de mayo 2021]; 111(6): 447-449. Disponible en: https://dx.doi.org/10.1016%2Fj.ad.2020.04.007.
González González F, Cortés Correa C, Peñaranda Contreras E. Manifestaciones cutáneas en pacientes con COVID-19: características clínicas y mecanismos fisiopatológicos postulados. Actas Dermo-Sifiliográficas [revista en internet]. 2021 [citado 24 de mayo 2021]; 112(4): 314-323. Disponible en: https://doi.org/10.1016/j.ad.2020.11.013.
Seeherman S, Suzuki YJ. Viral Infection and Cardiovascular Disease: Implications for the Molecular Basis of COVID-19 Pathogenesis. Int. J. Mol. Sci. [revista en internet]. 2021 [citado 24 de mayo 2021]; 22(4): 1659. Disponible en: https://www.mdpi.com/1422-0067/22/4/1659#.
Lo MW, Kemper C, Woodruff TM. COVID-19: Complement, Coagulation, and Collateral Damage. The Journal of Immunology [revista en internet]. 2020 [citado 24 de mayo 2021]; 205(6). Disponible en: https://doi.org/10.4049/jimmunol.2000644.
Orozco-Hernández JP, Marin-Medina DS, Sánchez-Duque JA. Manifestaciones neurológicas de la infección por SARS-CoV-2. Semergen [revista en internet]. 2020 [citado 24 de mayo2021]; 46(S1): 112-116. Disponible en: https://dx.doi.org/10.1016%2Fj.semerg.2020.05.004.
Published
How to Cite
Issue
Section
License
This journal provides free and immediate access to its content under the principle that making research freely available to the public supports a greater exchange of global knowledge. This means that the authors transfer the copyright to the journal, so that copies and distribution of the contents can be made by any means, as long as the authors' acknowledgment is maintained. These terms are a reflection that the journal assumes copyright under Creative Commons licenses, specifically under a Creative Commons Attribution 4.0 International license.
Registration and submission of articles to the journal is free. The processing, including review, editing and publication, is completely free of charge.