Possible predictors of abortion in first-trimester pregnant women infected with COVID-19
Keywords:
COVID-19, CORONAVIRUS INFECTIONS, PREGNANT WOMEN, ABORTION, PREGNANCY TRIMESTER, FIRST, ULTRASOUNDAbstract
Background: the information available about risk of miscarriage in pregnant women infected with SARS-CoV-2 is limited.
Objective: to determine the predictive value of variables that could have incidence of first trimester miscarriage in pregnant women infected with SARS-CoV-2, admitted in the Obstetric ward in the Cuban hospital in Qatar, from May 2020 to January 2021.
Methods: an observational, retrospective, case-control study to a sample obtained from pregnant patients in the first trimester, admitted to the hospital and time mentioned above, with positive rRT-PCR for SARS-CoV-2. They were distributed in two group: the cases with sonographic diagnosis of miscarriage and the control groups, without clinical suspicion of miscarriage, matched 1:2. The variables explored were age, obstetric antecedents, abortion antecedents, nutritional situation, comorbidity, chest x-rays evaluation.
Results: the average age was 31.39 years old. The most common comorbidity was the Diabetes mellitus, followed by hypotiroidism. The variables age (p=0.016), nutritional evaluation (p=0.000) and comorbidities (p=0.029) showed a relationship with miscarriage. A history of abortion increased the risk of miscarriage by 21 times, p=0.000.
Conclusions: a history of abortion constitutes a risk factor for miscarriage in pregnant women infected with COVID-19 during the first trimester of pregnancy. Age over 35 years, obesity and the presence of comorbidities, by themselves, are not risk factors, although associated they could increase the risk of miscarriage.
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Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patient infected with 2019 novel coronavirus in Wuhan, China. Lancet [revista en internet]. 2020 [citado 29 de junio 2022]; 395(10223): 497-506. Disponible en: https://doi.org/10.1016/S0140-6736(20)30183-5.
COVID-19 Map. Johns Hopkins Coronavirus Resource Center [en línea]. c2022 [actualizado 13 de junio 2020; citado 29 de junio 2022]. Disponible en: https://coronavirus.jhu.edu/map.html.
Knight et al. Characteristics and outcomes of pregnant women admitted to hospital with confirmed SARS-CoV-2 infection in UK: national population-based cohort study. BMJ [revista en internet]. 2020 [citado 14 de septiembre 2022]; 369. Disponible en: http://dx.doi.org/10.1136bmj.m2107.
Sosa-Frías A, Dornes-Ramon R, Mojena-Mojena O. Evolución de quince mujeres infectadas con la COVID-19 en el primer trimestre de su embarazo. Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta [revista en internet]. 2021 [citado 14 de septiembre 2022]; 46(6). Disponible en: http:// revzoilomarinello.sld.cu/index.php/zmv/article/view/2888.
Mayorga Albán SM, Valencia Escobar MN, Endara Salguero PE, Salas Hurtado IL. Embarazo e infección por coronavirus (COVID19). Journal of American Health [revista en internet]. 2021 [citado 29 de junio de 2022]; 4(1): 10-8. Disponible en: https://jah-journal.com/index.php/jah/article/view/58.
Cosma S, Carosso AR, Cusato J, Borella F, Carosso M, Bovetti M, et al. Coronavirus disease 2019 and first trimester spontaneous abortion: a case-control study of 225 pregnant patients. Am. J. Obstet. Gynecol. [revista en internet]. 2021 [citado 14 de julio 2022]; 224(4): 391.e1-7. Disponible en: https://www.ajog.org/article/S0002-9378(20)31177-7/fulltext.
Centro de prevención enfermedades. Investigacion De Impacto Covid 19 Embarazadas. [en línea]. 2020 [citado 15 de enero 2022]. Disponible en: https://espanol.cdc.gov/coronavirus/2019-ncov/cases-updates/special-populations/pregnancy-data-on-covid-19/what-cdc-is-doing.html.
Ranran Z, Yuelian Wu, Fangfang Z, Lv Y, Huang D, Wei J, et al. The risk of missed abortion associated with the levels of tobacco, heavy metals and phthalate in hair of pregnant woman. Medicine [revista en internet]. 2017 [citado 12 de agosto 2022]; 96(51). Disponible en: https://doi.org/10.1097%2FMD.0000000000009388.
Kaur M, Sharma P, Kaur R, Khetarpal. Increased incidence of spontaneous abortions on exposure to cadmium and lead: a systematic review and meta-analysis. Gynecological Endocrinology [revista en internet]. 2021 [citado 12 de agosto 2022]; 38(1): 16-21. Disponible en: https://www.tandfonline.com/doi/abs/10.1080/09513590.2021.1942450?journalCode=igye20.
Cheng-Yang H, Xiao-Jing Ya, Xiao-Guo H et al. Risk factors for spontaneous abortion from a prevention perspective in rural China: a population-based follow-up study, The Journal of Maternal-Fetal & Neonatal Medicine [revista en internet]. 2021 [citado 12 de agosto 2022]; 34(16): 2583-91. Disponible en: https://www.tandfonline.com/doi/abs/10.1080/14767058.2019.1670160?journalCode=ijmf20.
Narges K, Tahmineh G, Zahra M, Mohammad Ch, Salman G. Toxoplasma gondii infection and spontaneous abortion: A systematic review and meta-analysis. Microbial Pathogenesis [revista en internet]. 2021 [citado 15 de julio 2022]; 158(2018): 105070. Disponible en: https://doi.org/10.1016/j.micpath.2021.105070.
Chen B, Chen Y, Xu Y. Vitamin D deficiency in pregnant women: Influenced by multiple risk factors and increase the risks of spontaneous abortion and small-for-gestational age. Medicine (Baltimore) [revista en intrenet]. 2021 [citado 14 de julio 2022]; 100(41): e27505. Disponible en: https://doi:10.1097/MD.0000000000027505.
Guifang G, Caixin Y, Yanqing H, Yan Y, Ting H, Zhiqin Z, et al. A survey of influencing factors of missed abortion during the two-child peak period. Journal of Obstetrics and Gynaecology [revista en internet]. 2021 [citado 14 de junio 2022]; 41(6): 977-80. Disponible en: https://www.tandfonline.com/doi/abs/10.1080/01443615.2020.1821616?journalCode=ijog20.
Li J, Luo L, Diao J, Li Y, Zhang S, Chen L, et al. Male sperm quality and risk of recurrent spontaneous abortion in Chinese couples: A systematic review and meta-analysis. Medicine (Baltimore) [revista en internet]. 2021 [citado 20 de julio 2022]; 100(10): e24828. Disponible en: https://doi:10.1097/MD.0000000000024828.
Bi-Yun Z, Yi-Sheng W, Jian-Min N, Yi L, Zhu-Lin M, Zi-Neng W. Risk factors for unexplained recurrent spontaneous abortion in a population from southern China. International Journal of Gynecology & Obstetrics [revista en internet]. 2010 [citado 20 de septiembre 2022]; 108(2): 35-138. Disponible en: https://doi.org/10.1016/j.ijgo.2009.09.019.
Wang JX, Davies MJ, Norman RJ. Obesity Increases the Risk of Spontaneous Abortion during Infertility Treatment. Obesity Research [revista en internet]. 2002 [citado 28 de marzo 2022]; 10(6): 551-54. Disponible en: https://doi.org/10.1038/oby.2002.74.
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