Protective functions of saliva in caries prevention: a literature review
Keywords:
TOTAL ANTIOXIDANT CAPACITY, DENTAL CARIES, PREVENTION, SALIVA, XYLITOLAbstract
Background: introduction: saliva is an essential biological fluid in the maintenance of oral health, whose complex composition plays a protective role against oral diseases, especially dental caries. Through its physicochemical and biological properties, it contributes to the balance between demineralization processes and remineralization of enamel, acting as a natural defense system in the oral cavity.
Objective: to explain the protective functions of saliva in the prevention of tooth decay.
Methods: a literature review was carried out between February 1 and May 24, 2025, in databases such as PubMed, SciELO and Google Scholar. Descriptors such as; saliva; dental caries; antioxidant capacit; and; remineralization; were used. Original articles, reviews and clinical studies were included, prioritizing scientific evidence in Spanish and English.
Results: the saliva protects by cleaning mechanisms, pH buffering, acquired film formation and antimicrobial action. Its total antioxidant capacity counteracts oxidative stress generated by cariogenic bacteria. Factors such as hydration, diet and metabolic diseases hinder its composition and function. The use of non-cariogenic sweeteners, such as xylitol, has been shown to reduce the burden of Streptococcus mutans and enhance salivary protection.
Conclusions: the proper functioning of saliva depends on physiological and behavioral factors, so its care should be integrated into preventive dental strategies. Strengthening your functions through healthy habits is essential to maintain oral health.
Downloads
References
Márquez-Pérez K, Zúñiga-López CM, Torres-Rosas R, Argueta-Figueroa L. Reported prevalence of dental caries in Mexican children and teenagers. Rev. Med. Inst. Mex. Seguro Soc. [revista en internet]. 2023 [citado 2 de febrero 2025]; 61(5): 653–660. Disponible en: https://doi.org/10.5281/zenodo.8316465.
Enax J, Fandrich P, Schulze Zur WE, Epple M. The Remineralization of Enamel from Saliva: A Chemical Perspective. Dentistry journal [revista en internet]. 2024 [citado 2 de febrero 2025]; 12(11): 339. Disponible en: https://doi.org/10.3390/dj12110339.
Pineda-Ramírez NO, Sánchez-Narváez NB, Vega-Martínez VA. Propiedades bioquímicas de la Saliva en la salud bucal. SRS [revista en internet]. 2024 [citado 11 de mayo 2025]; 3(especial odontología): 316-21. Disponible en: https://doi.org/10.62574/2hvnb102.
Rado Castillo DR, Sauñe Intriago AÑ, Garay Gamboa HS, Cabrera Munares K, Valenzuela Ramos MR. La importancia de la saliva para la salud bucal. WHJ [revista en internet]. 2023 [citado 23 de mayo 2025]; 4(2): 26-41. Disponible en: https://doi.org/10.47422/whj.v4i2.40.
Pyati SA, Naveen Kumar R, Kumar V, Praveen Kumar NH, Parveen Reddy KM. Salivary Flow Rate, pH, Buffering Capacity, Total Protein, Oxidative Stress and Antioxidant Capacity in Children with and without Dental Caries. Journal of Clinical Pediatric Dentistry [revista en internet]. 2018 [citado 23 de mayo 2025]; 42(6): 445-9. Disponible en: https://doi.org/10.17796/1053-4625-42.6.7.
Hon L, Mohamed A, Lynch E. Reliability of colour and hardness clinical examinations in detecting dentine caries severity: a systematic review and meta-analysis. Sci Rep. [revista en internet]. 2019 [citado 23 de marzo 2025]; 6533 (2019). Disponible en: https://doi.org/10.1038/s41598-019-41270-6.
Pappa E, Vougas K, Zoidakis J, Papaioannou W, Rahiotis C, Vastardis H. Downregulation of Salivary Proteins, Protective against Dental Caries, in Type 1 Diabetes. Rev. Proteomes [revista en internet]. 2021 [citado 2 de abril 2025]; 9(3): 33. Disponible en: https://doi.org/10.3390/proteomes9030033.
Sánchez Savigñón M, Noa Pelier BY, Marrero Santana NT, Pèrez Pèrez N. Utilización del vendaje neuromuscular en el tratamiento de la sialorrea infantil asociada a enfermedades neurológicas. Medimay [revista en internet]. 2023 [citado 12 de mayo 2025]; 30(2): 135-42. Disponible en: https://revcmhabana.sld.cu/index.php/rcmh/article/view/1888.
Guillén-Miranda LE, Silva-Mata MA, Hernández-Lojano MP. Trastornos bucales en cuidados paliativos: abordaje de la xerostomía. Rev. Ciencias Médicas [revista en internet]. 2023 [citado 11 de abril 2025]; 27(Suplemento 2). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1561-31942023000800025&lng=es.
Okuyama K, Yanamoto S. Saliva in Balancing Oral and Systemic Health, Oral Cancer, and Beyond: A Narrative Review. Cancers [revista en internet]. 2024 [citado 19 de abril 2025]; 16(24): 4276. Disponible en: https://doi.org/10.3390/cancers16244276.
Fenoll-Palomares C, Muñoz-Montagud JV, Sanchiz V, Herreros B, Hernández V, Mínguez M, et al. Unstimulated salivary flow rate, pH and buffer capacity of saliva in healthy volunteers. Rev. Esp. Enferm. dig. [revista en internet]. 2004 [citado 24 de mayo 2025]; 96(11). Disponible en: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082004001100005&lng=en&nrm=iso&tlng=en.
Ahmad P, Hussain A, Carrasco-Labra A, Siqueira WL. Salivary Proteins as Dental Caries Biomarkers: A Systematic Review. Caries Res. [revista en internet]. 2022 [citado 24 de mayo 2025]; 56(4): 385-98. Disponible en: https://doi.org/10.1159/000526942.
Petrović B, Stilinović N, Tomas A, Kojić S, Stojanović GM. Determination of salivary concentrations of leptin and adiponectin, ability to reduce ferric ions and total antioxidant capacity of saliva in patients with severe early childhood caries. Front Pediatr. [revista en internet]. 2022 [citado 31 de marzo 2025]; 10(2022). Disponible en: https://doi.org/10.3389/fped.2022.969372.
Martins JR, Díaz-Fabregat B, Ramírez-Carmona W, Monteiro DR, Pessan JP, Antoniali C. Salivary biomarkers of oxidative stress in children with dental caries: Systematic review and meta-analysis. Archives of Oral Biology [revista en internet]. 2022 [citado 1 de abril 2025]; 139(2022). Disponible en: https://doi.org/10.1016/j.archoralbio.2022.105432.
Liang NL, Luo BW, Sun IG, Chu CH, Duangthip D. Clinical Effects of Sugar Substitutes on Cariogenic Bacteria: A Systematic Review and Meta-Analysis. International Dental Journal [revista en internet]. 2024 [citado 4 de abril 2025]; 74(5): 987-98. Disponible en: https://doi.org/10.1016/j.identj.2024.02.008.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Paola Nicole Eugenio-Torres, Gabriela María Tibán-Morocho , Vianka Anahí Cuadrado-Carrasco

This work is licensed under a Creative Commons Attribution 4.0 International License.
This journal provides free and immediate access to its content under the principle that making research freely available to the public supports a greater exchange of global knowledge. This means that the authors transfer the copyright to the journal, so that copies and distribution of the contents can be made by any means, as long as the authors' acknowledgment is maintained. These terms are a reflection that the journal assumes copyright under Creative Commons licenses, specifically under a Creative Commons Attribution 4.0 International license.
Registration and submission of articles to the journal is free. The processing, including review, editing and publication, is completely free of charge.
