Clinical, epidemiological and genetic characterization of patients under 25 years old with Diabetes Mellitus
Keywords:
DIABETES MELLITUS, ADOLESCENT, HEREDITY, GENETICSAbstract
Background: patients under 25 years old begin with different clinical forms of diabetes mellitus: type 1 and 2, of known causes, and those starting at the maturity of young people, monogenic diabetes, with an autosomal dominant inheritance pattern.
Objective: to characterize, according to clinical, epidemiological and genetic variables, patients under 25 years old who suffer from diabetes mellitus of the Provincial Diabetes Care Center of Las Tunas.
Methods: an observational, descriptive and prospective study was carried out in 19 patients diagnosed with diabetes mellitus and treated at the mentioned center during two years. The variables measured were: starting age, sex, nutritional assessment, blood glucose levels at the beginning, associated diseases and family history of diabetes mellitus.
Results: females prevailed with 68,4 %, and the age group diagnosed was between 15 and 19 years (57,9 %) in both sexes. 59,7 % of the patients were normo-weight. 47,4 % had blood glucose levels above 20 mmol / L at the start. The most frequently associated diseases were hypertension and thyroid disease. The same quantity of patients had first and second degree relatives with diabetes mellitus and ten had third degree relatives.
Conclusions: it was possible to characterize the study population, in which there was a greater association with thyroid conditions and high blood pressure and with family history of diabetes mellitus in three consecutive generations.
Downloads
References
Pérez C L. Diabetes Mellitus en Bioquímica Clínica para Tecnología de la salud. Cap. 12. Cuba: ECIMED; 2012. Disponible en: http://www.bvs.sld.cu/libros_texto/bioquimica_clinica/cap12.pdf.
Guilarte Selva OT, Álvarez Cortés JT, Selva Capdesúñer A, Bonal Ruiz R, Salazar Duany Z. Caracterización clinicoepidemiológica de pacientes diabéticos en un área de salud. MEDISAN [revista en internet]. 2013, Mayo [citado 6 de junio 2016]; 17(5): 820-827. Disponible en: http://scielo.sld.cu/ scielo.php?script=sci_arttext&pid=S1029-30192013000500010&lng=es.
Prevalencia de diabetes mellitus, hipertensión arterial y asma bronquial según grupo de edad y sexo. 2012. Ministerio de Salud Pública-Dirección Nacional de Registros Médicos y Estadísticas de Salud. La Habana: Editorial MINSAP; 2012. Disponible en: http://www.infomed.sld.cu.
Arnold Y, Licea M, Aldana D. Aspectos relevantes de la epidemiología de la diabetes mellitus en Cuba. Rev. Peruana de epidemiología [revista en internet]. 2011 [citado 6 de junio 2016]; 15(3). Disponible en: https://dialnet.unirioja.es/servlet/articulo?codigo=3994639.
Tapia Ceballos L. Diabetes MODY. Una causa frecuente de hiperglucemia. An Pediatr (Barc) [revista en internet]. 2008 [citado 6 de junio 2016]; 69(6): 565-7. Disponible en: http://www.sciencedirect.com/ science/article/pii/S1695403308752408.
Girón Bombull JA, Fernández González A, Trujillo Feliciano Y, Ramos Labrada N, Silva Durán O. Caracterización clinicoepidemiológica de la prediabetes. MEDISAN [revista en internet]. 2013, Ago [citado 6 de junio 2016]; 17(8): 2096-3000. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_art text&pid=S1029-30192013000800002&lng=es.
Laffel L, Svoren B. Epidemiology, presentation, and diagnosis of type 2 diabetes mellitus in children and adolescents. 2012. Disponible en: http://www.uptodate.com/contents/management-of-type-2-diabetes-mellitus-in-children-and-adolescents?source=search_result&search=Epidemiology%2C+presentation% 2C+and+diagnosis+of+type+2+diabetes+mellitus+in+children+and+adolescents&selectedTitle=2~150.
Rojas J, González R, Chávez M, Salazar J, Añez R, Chacín M, Cano C, Bermúdez V. Diabetes mellitus type 2, natural history of the disease, and experience in the Endocrine Metabolic Reseach Centre “Dr. Félix Gómez. Revista Diabetes Internacional [revista en internet]. 2013 [citado 6 de junio 2016]; 5(1). Disponible en: http://www.diabetesinternacional.com/index_edicion1_2013.html.
Fajans S, Bell GI. MODY: History, genetics, pathophysiology and clinical decision making. Diabetes care [revista en internet]. 2013 [citado 6 de junio 2016]; 34(8): 1878-1884. Disponible en: http://care. diabetesjournals.org/content/34/8/1878.short.
Conesa González AI, González Calero TM. Aspectos más recientes en relación con la diabetes mellitus tipo MODY. Rev Cubana Endocrinol [revista en internet]. 2012, Ago [citado 6 de junio 2016]; 23(2): 186-194. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1561-29532012000200 008&lng=es.
Pérez Agramonte Y, Rodríguez Valido Y, Quesada Ravelo O. La Diabetes Mellitus y su relación con enfermedades cardiovasculares. CorSalud [revista en internet]. 2013 [citado 6 de junio 2016]; 5(3). Disponible en: http://www.corsalud.sld.cu/sumario/2013/v5n3a13/cartasv5n3.html#diabetes.
Navarrete J. Caracterización clínico-epidemiológica de los pacientes con Diabetes mellitus en menores de 15 años de edad. Ciudad Habana: 2000- 2008. La Habana: Instituto Nacional De Endocrinología; 2010.
American Diabetes Association. Diagnosis and Classification of Diabetes Mellitus. Definition and description of diabetes mellitus. Diabetes Care [revista en internet]. 2012, Ene [citado 6 de junio 2016]; 35(Sup1): S64-S71. Disponible en: http://dx.doi.org/10.2337/dc12-s064.
Osório J. Looking at the epigenetic link between obesity and its consequences—the promise of EWAS. Nature Reviews Endocrinology [revista en internet]. 2014 [citado 6 de junio 2016]; 10(5): 249. Disponible en: http://www.nature.com/nrendo/journal/v10/n5/full/nrendo.2014.42.html.
Osório J. Cilia length—role in energy balance. Nature Reviews Endocrinology [revista en internet]. 2014 [citado 6 de junio 2016]; 10(6): 313. Disponible en: http://www.nature.com/nrendo/journal/v10/n6/full /nrendo.2014.53.html.
Lozano Álvarez EE. Algunas consideraciones sobre la diabetes mellitus. CCM [revista en internet]. 2014, Mar [citado 6 de junio 2016]; 18(1): 122-125. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_ arttext&pid=S1560-43812014000100016&lng=es.
ABC En el diagnóstico y tratamiento en Endocrinología. Instituto Nacional de Endocrinología: Sociedad Cubana de Endocrinología; 2011.
American Diabetes Association. Diabetes Mellitus: Normas de diagnóstico y tratamiento 2014. Las recomendaciones para el manejo de la diabetes en adultos y niños del National Glycohemoglobin Standarization Program. Diabetes Care [revista en internet]. 2014 [citado 6 de junio 2016]; 37(1). Disponible en: http://care.diabetesjournals.org/.
Steele A, Shields BM, Shepherd M, Ellard S, Colcloug K, Hattersley AT. Microvascular complication risk in patients with 50 years of moderate hyperglycaemia: are target ranges for glycaemic control appropriate? Diabet Med [revista en internet]. 2011 [citado 6 de junio 2016]; 28(supl1): 28. Disponible en: http://onlinelibrary.wiley.com/doi/10.1111/j.1464-5491.2011.03232_17.x/pdf.
MODY (Report) [en línea]. Case report. Retrieved Jan 25; 2010 [citado 6 de junio de 2016]. Disponible en: http://www.Phlaunt.com/diabetes/14047009.php.
Renal Cysts and Diabetes Syndrome; RCAD (Report) [en línea]. Case report. Retrieved May 19; 2011. Disponible en: http://www.omim.org/entry/137920?search=48.%09Renal%20Cysts%20and%20Diabe tes%20Syndrome&highlight=cysts%20diabete%20syndrome%2048%20syndromic%20diabetic%20cyst%20renal%2048.%09renal%20diabetes.
McDonald TJ, Colclough K, Brown R, Shields BM, Shepherd MH, Bingley P, et al. Islet autoantibodies can discriminate maturity-onset diabetes of the Young (MODY) from type 1 diabetes. Diabet Med [revista en internet]. 2011 [citado 6 de junio 2016]; 28(9): 1028-33. Disponible en: http://onlinelibrary.wiley.com/ doi/10.1111/j.1464-5491.2011.03287.x/full.
Pérez LM, Álvarez A, Domínguez E, Juí JA, Rodríguez J, Pereira Y, et al. Variantes polimórficas Ala513Pro y Gly972Arg del gen IRS-1 no se asocian a la diabetes mellitus tipo 2 en un grupo de la población cubana. Rev Cubana Endocrinol [revista en internet]. 2011, Ago [citado 6 de junio 2016]; 22(2): 91-102. Disponible en: http://scieloprueba.sld.cu/scielo.php?script=sci_arttext&pid=S1561-295320110002 00004&lng=es.
Schwitzgebel V. Many faces of monogenic diabetes. J Diabetes Invest [revista en internet]. 2014 [citado 6 de junio 2016]; 5(2): 121–133. Disponible en: http://onlinelibrary.wiley.com/doi/10.1111/jdi.12197/ full.
Awa WL, Thon A, Raile K, Grulich-Henn J, Meissner T, Schober E, et al. Genetic and clinical characteristics of patients with HNF1A gene variations from the German–Austrian DPV database. European Journal of Endocrinology [revista en internet]. 2011 [citado 6 de junio 2016]; 164(4): 513–520. Disponible en: http://www.eje-online.org/content/164/4/513.short.
Downloads
Published
How to Cite
Issue
Section
License
This journal provides free and immediate access to its content under the principle that making research freely available to the public supports a greater exchange of global knowledge. This means that the authors transfer the copyright to the journal, so that copies and distribution of the contents can be made by any means, as long as the authors' acknowledgment is maintained. These terms are a reflection that the journal assumes copyright under Creative Commons licenses, specifically under a Creative Commons Attribution 4.0 International license.
Registration and submission of articles to the journal is free. The processing, including review, editing and publication, is completely free of charge.