Results of the Diagnosis National Program of HLA-B27 in patients from Las Tunas

Authors

  • Enelis Reyes Reyes Departamento Provincial de Genética Médica. Las Tunas
  • Isabel Cristina Tamayo Áreas Hospital General Docente "Dr. Ernesto Guevara de la Serna". Las Tunas
  • Maidelina Cardoso Paredes Departamento Provincial de Genética Médica. Las Tunas

Keywords:

SPONDYLARTHROPATHIES, HLA-B27 ANTIGEN

Abstract

Background: Cuba has started a national program to diagnose the human leukocyte antigen B27 (HLA-B27) through molecular analysis, considering this antigen as a genetic marker for susceptibility to spondylo-arthropathies.

Objective: to describe the results of the national program to diagnose the HLA-B27 in patients from Las Tunas province.

Methods: a retrospective-descriptive study was carried out from 2012 to 2015, using as a study population the 126 patients in genetic record, who were prescribed the HLA-B27. The socio-demographic variables and results were assessed.

Results: 17,4 % of positivity was found in the study population, representing a rate of 0,04 per each 1000 inhabitants of our province. In the positive cases males predominated and the age group was modified by sex, in males the age group between 31 and 40 years prevailed, while in females it was from 21 to 30 years old. Las Tunas, followed by Jobabo, were the municipalities with the highest positivity.

Conclusions: the diagnosis national program of HLA-B27 was applied in the province, with detection of a higher incidence in Las Tunas municipality.

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Author Biographies

Enelis Reyes Reyes, Departamento Provincial de Genética Médica. Las Tunas

Especialista de Segundo Grado en Inmunología. Máster en Enfermedades Infecciosa, Investigador agregado. Profesor Asistente.

Isabel Cristina Tamayo Áreas, Hospital General Docente "Dr. Ernesto Guevara de la Serna". Las Tunas

Especialista de Primer Grado en Reumatología. Profesor Instructor.

Maidelina Cardoso Paredes, Departamento Provincial de Genética Médica. Las Tunas

Licenciada en Enfermería.

References

Torres Odio S, Martínez Córdova Z. Factores genéticos, inmunológicos y ambientales asociados a la autoinmunidad. Rev Cubana Invest Bioméd [revista en internet]. 2011 [citado 7 de abril 2016]; 30(4): 501-510. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864-03002011000400008.

Velásquez EP, Quintero JC, Aristizábal BH, Rincón OL, Velásquez CJ, Pinto LF, Márquez JD Frecuencia de alelos HLA de clase I y II en una cohorte de pacientes con espondiloartritis provenientes del noroccidente colombiano. Biomédica [revista en internet]. 2012 [citado 7 de abril 2016]; 32(1). Disponible en: http://www.scielo.org.co/pdf/bio/v32n1/v32n1a06.

Bautista-Molano WA, Londoño John D, Romero Sánchez C, Ávila Mabel, Valle RR. Espondiloartritis y su asociación con el Complejo Mayor de Histocompatibilidad. Rev. Colomb. Reumatol [revista en internet]. 2011, Enero [citado 7 de abril 2016]; 18(1): 34-41. Disponible en: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0121-81232011000100004&lng=en.

Reveille J D. Genetics of spondyloarthritis—beyond the MHC. Nature Reviews Rheumatology [revista en internet]. 2012 [citado 7 de abril 2016]; 8(5): 296-304. Disponible en: http://www.nature.com/nrrheum/journal/v8/n5/abs/nrrheum.2012.41.html.

Reveille J D. Spondyloarthritis. Clinical immunology [revista en internet]. 2013 [citado 7 de abril 2016]; 56: 676-692. Disponible en http://www.clinicalKey.com.

Hill Gaston. Mechanisms of Disease: the immunopathogenesis of spondyloarthropathies. Nature Clinical Practice Rheumatology [revista en internet]. 2006 [citado 7 de abril 2016]; 2(7): 383-392. Disponible en: http://www.nature.com/nrrheum/journal/v2/n7/full/ncprheum0219.html.

Stolwijk C, Boonen A, Van Tubergen A, Reveille J D. Epidemiology of spondyloarthritis. Rheum. Dis. Clin. North Am [revista en internet]. 2012 [citado 7 de abril 2016]; 38(3): 441–476. Disponible en: http://www.sciencedirect.com/science/article/pii/S0889857X12000816.

Van Tubergen A. The changing clinical picture and epidemiology of spondyloarthritis. Nature Reviews Rheumatology [revista en internet]. 2015 [citado 7 de abril 2016]; 11(2): 110-118. Disponible en: http://www.nature.com/journal/nrrheum.2014.181.

Van den Berg R, de Hooge M, Rudwaleit M, Sieper J, Van Gaalen F, Reijnierse M, Van der Heijde D. ASAS modification of the Berlin algorithm for diagnosing axial spondyloarthritis: results from the SPondyloArthritis Caught Early (SPACE)-cohort and from the Assessment of SpondyloArthritis international Society (ASAS)-cohort. Ann. Rheum. Dis [revista en internet]. 2013 [citado 7 de abril 2016]; 72(10): 1646–1653. Disponible en: http://www.nature.com.

Velásquez EP, Quintero JC, Aristizábal BH, Rincón OL, Velásquez CJ, Pinto LF, Márquez JD. Frecuencia de alelos HLA de clase I y II en una cohorte de pacientes con espondiloartritis provenientes del noroccidente colombiano. Biomédica [revista en internet]. 2012 [citado 7 de abril 2016]; 32(1). Disponible en: http://www.scielo.org.co/pdf/bio/v32n1/v32n1a06 o.

Jiao Y L, Zhang B C, You L, Li J F, Zhang J, Ma C Y, Zhao Y R. Polymorphisms of KIR Gene and HLA-C Alleles: Possible Association with Susceptibility to HLA-B27-Positive Patients with Ankylosing Spondylitis. J Clin Immunol [revista en internet]. 2010 [citado 7 de abril 2016]; 30(6): 840–844. Disponible en: http://link.springer.com/article/10.1007/s10875-010-9444-z.

Ortiz Peña P, Calvo Páramo E, Varela P, Valle R, Londoño Patiño J. Entesis, entesopatía y espondiloartritis. Rev. Colomb. Reumatol [revista en internet]. 2012, Ene [citado 7 de abril 2016]; 19(1): 34-41. Disponible en: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0121-81232011000100004&lng=en.

Colbert Robert A. Classification of juvenile spondyloarthritis: enthesitis-related arthritis and beyond. Nature Reviews Rheumatology [revista en internet]. 2010 [citado 7 de abril 2016]; 6(8): 477-485. Disponible en: http://www.nature.com/nrrheum/journal/v6/n8/abs/nrrheum.2010.103.html.

Salvo G L. Magnitud, impacto y estrategias de enfrentamiento de la depresión, con referencia a Chile. Rev. méd. Chile [revista en internet]. 2014, Sep [citado 7 de abril 2016]; 142(9): 1157-1164. Disponible en: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872014000900010&lng=es. http://dx.doi.org/10.4067/S0034-98872014000900010.

Estivill PX, Gratacós MM. Genética de las enfermedades compleja. En: Farreras-Rozman. Medicina interna; 2013. Cap 150. p. 1167-1173. Disponible en http://www.clinicalkey.es.

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Published

2016-04-06

How to Cite

1.
Reyes Reyes E, Tamayo Áreas IC, Cardoso Paredes M. Results of the Diagnosis National Program of HLA-B27 in patients from Las Tunas. Rev. electron. Zoilo [Internet]. 2016 Apr. 6 [cited 2026 Jan. 21];41(5). Available from: https://revzoilomarinello.sld.cu/index.php/zmv/article/view/741

Issue

Vol. 41 No. 5 (2016): May (Genetics)

Section

Brief communications

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